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Camila Giorgi of Italy returns a shot to Caroline Wozniacki of Denmark during the Connecticut Open at the Connecticut Tennis Center at Yale on August 20, 2014 in New Haven, Connecticut. Image Credit: AFP

New Haven & Winston-Salem: Camila Giorgi sprang an upset to defeat four-time champion Caroline Wozniacki 6-4, 6-2 on Wednesday and reach the quarter-finals of the WTA Connecticut Open, a final warm-up for the US Open.

The Italian saw off the former world number one in 78 minutes to book a last-eight date with Spain’s Garbine Muguruza, who eliminated Chinese qualifier Peng Shuai 6-2, 3-6, 6-3 in another second-round match.

The unseeded Giorgi also ousted Wozniacki in last year’s US Open, but lost their only other meeting this year at Eastbourne.

Wozniacki, whose best Grand Slam showing was a 2009 US Open runner-up effort, won the title at New Haven from 2008 to 2011, but saw her record at the Yale University event dip to 24-3.

The 24-year-old Dane’s only prior losses since Wimbledon came in three-set battles with world number one Serena Williams in Montreal and Cincinnati.

“I knew I was going to get limited break chances and when I did get them, I didn’t convert,” Wozniacki said. “I knew I had to be aggressive out there and try to push her back, but I didn’t manage to do that. She played well and I didn’t.”

The defeat does allow Wozniacki a few extra days to prepare for the year’s final Grand Slam, which starts on Monday.

“I would have loved to have been here longer, but it wasn’t to be this year,” Wozniacki said. “Now I just need to take the positives out of it. I get a few extra days to rest up and practice for the US Open.”

Wimbledon finalist Eugenie Bouchard also failed to make it to the quarter-finals.

Australian veteran Samantha Stosur briskly ousted the third-seeded Canadian 6-2, 6-2.

Stosur next faces Belgian Kirsten Flipkens, who beat Germany’s Andrea Petkovic 4-6, 7-6 (7/4), 7-6 (8/6).

Thursday’s other two quarter-finals were already set. Slovakian Magdalena Rybarikova, who ousted top-seeded Simona Halep, will take on American Alison Riske, and second-seeded Wimbledon champion Petra Kvitova will face fellow Czech Barbora Zahlavova Strycova.

Meanwhile, two-time champion John Isner made it safely into the quarter-finals of the ATP hardcourt tournament at Winston-Salem on Wednesday, where compatriot Sam Querrey toppled second-seeded Kevin Anderson in straight sets.

Querrey, seeking a third straight semi-final appearance in the US Open tune-up, downed Anderson 7-6 (7/4), 6-4 to stretch his career record over the South African to 7-4.

“I played great out there. That was the best I’ve played all summer,” said the 56th-ranked Querrey. “I was aggressive the whole time and returned well. I thought everything went pretty well.”

Querrey next faces Spanish fifth seed Guillermo Garcia-Lopez, who saved two match points in a 6-7 (4/7), 6-3, 7-6 (8/6) win over American Donald Young.

Isner, the top seed, defeated 13th seed Mikhail Kukushkin of Kazakhstan 6-1, 7-6 (7/3). Isner, a North Carolina native who won this title in 2011 and 2012, didn’t face a break point in the 68-minute match, firing 17 aces.

In Thursday’s quarter-finals, Isner will face seventh-seeded Czech Lukas Rosol, who beat Spain’s Pablo Andujar 1-6, 6-2, 6-2.

Taiwan’s Lu Yen-Hsun also booked a quarter-final berth, cruising past Spain’s Marcel Granollers 6-1, 6-2.

He’ll face Andreas Seppi of Italy, who beat France’s Nicolas Mahut 6-4, 7-6 (9/7).

Belgian qualifier David Goffin extended his unbeaten run to 25 matches, beating Finland’s Jarkko Nieminen 6-4, 4-6, 6-4 to set up a clash with Jerzy Janowicz. Poland’s Janowicz dispatched France’s Edouard Roger-Vasselin 4-6, 6-3, 6-4.

“It was a great fight and I’m really happy the way I played at the end to win this match,” said Goffin, who hasn’t lost a match since his first-round exit at Wimbledon.

“Of course, after 25 matches you have a lot of confidence, you don’t think you’re going to lose, but I play every match like it’s the first one in the tournament, like it’s the first one of the season and I give everything.”